The purpose of this study was to determine the optimal bolus/infusion ratio of urokinase UK in a dog model of experimental thrombosis. Radiolabelled clots from dog whole blood were inserted into an extra corporeal jugular loop in anesthetized
A fat emulsion for infusion by vein Intrafat recently developed in Japan consists of a 10 solution of soya bean oil with egg yolk phospholipid as emulsifier and 2.5 glycerol to render it isotonic. Experimental studies with dogs and clinical trials with surgical patients are described. Side effects were very mild and there was no sign of overloading.
Jan 01 2017 Although infusion models are not limited to these species alone for the purpose of this chapter discussion will be limited to the rat dog and NHP as general assumptions regarding infusion techniques processes catheter maintenance and equipment can be extrapolated across multiple species including the mouse rabbit and mini pig.
May 23 2017 dosing a larger quantity of solution is necessary infusion of the dose IV over greater than 5 minutes should be considered and should not exceed 10 of the circulating blood volume over 2 hours. Rats may be given daily IV injections of isotonic saline at up to 80 ml/kg at 1 ml/min. for 4 days. Intra arterial administration should be
The aim of this work was to evaluate the effects of etomidate intravenous infusion on intracranial pressure and cardiac parameters in dogs. Ten healthy adults dogs male and females ones whose weight ranged from 4.8 to 11.7 kg were used. General anesthesia was induced using intravenously etomidate at a dose of 5 mg/kg.
Jul 01 2002 Implantable infusion pumps for use in larger laboratory animals species including dogs and nonhuman primates are not commonly used. One device the Esox Pump Advanced Neuromodulation Systems Inc. Plano Texas is an elastomeric implantable pump that has been adapted from the clinical market and can be utilized in rats >250 g and in larger
Objective To establish the correlation between the bispectral index BIS and different rates of infusion of propofol in dogs. Study design Prospective experimental trial. Animals Eight adult dogs weighing 6 20 kg. Methods Eight animals underwent three treatments at
greater decrease in flow with the intraarterial infusion. The rhesus monkey was chosen for the present study for several reasons. Canine studies are limited by ana tomical and physiological differences between dogs and human beings an example of which is the mucosal
Keywords psychedelic drugs dimethyltryptamine ayahuasca hallucinations consciousness intravenous infusion pharmacokinetic modeling. Citation Gallimore AR and Strassman RJ 2016 A Model for the Application of Target Controlled Intravenous Infusion for a Prolonged Immersive DMT Psychedelic Experience. Front.
Hemodynamic effects of an intravenous infusion of medetomidine at six different dose regimens in isoflurane anesthetized dogs Veterinary therapeutics research in applied veterinary medicine 2010 Eric Troncy
The aim of this study was to determine whether the addition of constant rate infusion CRI to intermittent intravenous bolus IVB administration of furosemide resulted in an improvement in medical outcomes in dogs and cats with acute left sided congestive heart failure L CHF . A total of 76 client owned dogs and 24 client owned cats admitted
Aug 02 2013 In the other study dogs received a constant intravenous infusion of vehicle normal saline at a volume and rate identical to that used for GP531. GP531 or vehicle was administered as a continuous intravenous infusion for 6 h. Hemodynamic angiographic and echocardiographic measurements were made at baseline prior to drug administration and at
Intravenous infusion in dogs and primates. Int J Toxicol 13 40–47 Google Scholar 99. Phalen RF Mendez LB. 2009. Dosimetry considerations for animal aerosol inhalation studies. Biomarkers 14 Suppl 1 63–66 PMC free article Google Scholar 100.
Aug 31 2000 The Handbook of Pre clinical Continuous Intravenous Infusion answers the needs of researchers and technicians by providing complete instructions for a wide range of infusion techniques delivered to several species. With sections devoted to rats mice rabbits dogs mini pigs and nonhuman primates both large and small this thorough text
Aug 21 2016 2.5 5 mg kg IV bolus maintenance with 0.3 0.4 mg/kg/min IV constant rate infusion 11 38 109 111 119 Baboons macaques 7 8 mg/kg IV 34 Marmosets larger primates/induction and maintenance of anesthesia good surgical anesthesia and rapid smooth recovery 38 44 1 2 mg/kg IV bolus followed by infusion to effect 109 Chimpanzees
Jul 20 2018 Fentanyl lidocaine or ketamine can be used in association with a total intravenous anesthesia TIVA with propofol. The use of fentanyl lidocaine ketamine FLK reduced the minimum alveolar concentration of isoflurane by 97 in dogs and fentanyl loading dose LD 0.005 mg kg 1 and constant rate infusion CRI 0.0001 mg kg 1 hr 1 decreased
3. Four dogs 2 male 2 female prepared for urine collections and for blood pressure and heart rate determinations were given saline or dextrose intravenously at infusion rates of 0.3 ml kg min 1 1.0 ml kg min 1 or 3.0 ml kg min 1 for 60 min a sham infusion was also performed. 4.
IV Fluid Therapy Calculations Once the overall fluid rate per hour has been calculated taking into consideration maintenance deficit and on going loss this information can be entered into an infusion pump if this is available. If not a drip rate needs to be calculated in mL/minute e.g. A dog needs 116mL/hour 116mL/hour/60 = 1
VAPs connect to an implanted vascular catheter but are enclosed under the skin layer making it possible to group house after recovery. When needed the port is accessed using a non coring Huber needle. SAI offers ports catheters and jackets to ensure that your dog dosing and sampling is successful.
o Single intravenous IV infusion 1.1 10 14 human primates NHPs administered an AAVhu68 vector via the IV route 2 No adverse liver
Intravenous infusions of dextran were given to dogs with gastric pouches to two healthy human subjects and to a patient with intestinal fistulae. A semi quantitative serological method indicated the presence of dextran in the digestive tract but in such low concentrations as to have little practical significance. M. B. Richards.
Mar 01 1993 Based on an estimated average dog weight of 12.0 kg and an estimated extracellular fluid volume of 20 of body weight 200ml/kg the amount of volume expansion during the infusion period was about 40 ml/kg for the 1.0 ml kg min t infusion rate and approx. 125 ml/kg at the 3.0 ml kgmin infusion rate representing 20 and 60 expansion of
In critically ill dogs and cats veterinarians should titrate IV fluid therapy with the aim of achieving fluid balance. a. 0 b. 10 c. 20 d. 30 Chloride rich IV fluids such 0.9 saline are indicated in cases of a. Feline urethral obstruction with severe hyperkalemia K >8 mEqL b. Hemorrhagic shock
Continuous intravenous infusion allows the intended clinical dosing regime to be better evaluated during preclinical studies. Depending on the test material and vehicle infusion for up to 6 months in primates and 12 months in beagle dogs is possible but 28 days is the most frequent duration.
Dogs were given buprenorphine s.c. by use of an implantable osmotic pump 4 dogs morphine s.c. by use of a preset infusion pump 4 or buprenorphine intra arterially by use of a programmable infusion pump 2 .Dogs were monitored and serum buprenorphine or morphine concentration was measured for 72 hours after surgery pumps were removed 48
Biochemical changes were monitored during fat infusion as part of an evaluation of the toxicity that accompanies the intravenous administration of a new soybean oil emulsion in dogs. Beagles were given FE S15 at 9 and 4 g/kg/day for 28 days via a central venous catheter. The total serum lipid trigl
Infusion of RL in vagotomised and/or carotid sinus CS denervated dogs and in spinal dogs indicated that these neural pathways had a significant effect on basal amplitude of ECG waves but their influence on infusion induced ECG changes was only marginal in this the vagi seem to have a greater influence than the other pathways.
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